Administer busulfex in combination with cyclophosphamide as a conditioning regimen prior to bone marrow or peripheral blood progenitor cell replacement. Nail changes can occur such as dark lines or changes in color. Cyclophosphamide pharmacokinetics and dose requirements account. The unchanged drug has an elimination halflife of 3 to 12. Cyclophosphamide is a known teratogen with significant limb abnormalities and cognitive impairment resulting from firsttrimester exposure. The chemical name for cyclophosphamide is 2 h1,3,2oxazaphosphorin2amine, n,nbis2chloroethyltetrahydro, 2oxide, monohydrate. Definition from the nci drug dictionary detailed scientific definition and other. Although women taking cyclophosphamide can stop having periods, they can still become pregnant, so an effective form of. The chemical name for cyclophosphamide is 2bis2chloroethylaminotetrahydro2h1,3,2oxazaphosphorine 2. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. I thank the cyclophosphamide and all my teachers past, present, and future for. The recommended dosage and schedule in combination with fludarabine and cyclophosphamide is. Sandoz launches first generic version of cyclophosphamide. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279.
Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h. Dose increase or reduction is recommended based on individual safety and tolerability. Instances of lifethreatening and sometimes fatal autoimmune phenomena such as hemolytic anemia, autoimmune thrombocytopenia thrombocytopenic purpura itp, evans syndrome, and acquired. Cytoxan cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Mesnex is indicated as a prophylactic agent in reducing. Dailymed cyclophosphamide injection, powder, for solution. Development of sterility appears to depend on the dose of cyclophosphamide, duration. Lyophilized cytoxan cyclophosphamide for injection, usp. Rheumatoid arthritis ra rituxan rituximab in combination with methotrexate is indicated for the treatment of adult. Cyclophosphamide is also being studied in the treatment of other types of cancer. Cyclophosphamide use with enbrelis not recommended 7.
Etopophos is a topoisomerase inhibitor indicated for the treatmentof patients with. For infusion, cyclophosphamide should be reconstituted by adding. Multiple myelomas myeloma stages ii, iiia, iiib see also dosage and administration 3. This solution is readytouse and may be administered directly to the patient without further preparation. Highlights of prescribing information palmarplantar.
Adapted from standard reference11 unless specified otherwise. Cytoxan cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Cyclophosphamide interferes with oogenesis and spermatogenesis. Anthracyclines including doxorubicin should not be administered in combination with other cardiotoxic agents unless. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for cytoxan cyclophosphamide skip to. Lyra study habte yimer,1 jason melear,2 edward faber,3 william i. Farber cancer institute last revised 22018 patient and family education committee 4. Cyclophosphamide pharmacokinetics and dose requirements. Central venous access is recommended for administration of this agent. See the enbreletanercept instructions for use insert for detailed information. Cytoxan fda prescribing information, side effects and uses. The preferred diluent is 5% dextrose injection, usp.
Secondary malignancies have been associated with this drug. Cyclophosphamide can cause infertility in both men and women. Cyclophosphamide fda prescribing information, side. Vincristine sulfate vincristine sulfate this product information is intended only for residents of the united states. It is eliminated primarily in the form of metabolites. Camptosar is intended for dilution with 5% dextrose injection, usp d5w, or 0. Over the course of treatment, patients who tolerate inlyta for at least two. Cyclophosphamide is soluble in water, saline and ethanol. Cyclophosphamide is well absorbed after oral administration with a bioavailability greater than 75%. Administer a lymphodepleting regimen of cyclophosphamide and fludarabine before infusion of yescarta 2. Review drug package insert for additional information. These highlights do not include all the information needed to use. Acute infusionrelated reactions including, but not limited to, flushing, shortness of breath, facial swelling. Ifosfamide and mesnex may be mixed in the same bag provided the final concentration of ifosfamide does not exceed 50 mgml.
Cyclophosphamide is well absorbed after oral administration with. The unchanged drug has an elimination halflife of 3 to 12 hours. Daratumumab, bortezomib, cyclophosphamide and dexamethasone in newly diagnosed and relapsed multiple myeloma. Cytoxan cyclophosphamide for injection, usp cytoxan. Refractory testicular tumors, in combination with other chemotherapeutic drugs. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279.
See full prescribing information for complete boxed warning. Toxic deaths, hepatotoxicity, neutropenia, hypersensitivity reactions, and fluid retention 1 indications and usage. Cyclophosphamide should only be used by clinicians experienced in the use of cancer chemotherapy. If previously receiving 60 mg daily dose, resume treatment at 40 mg daily. Medscape indicationspecific dosing for cytoxan cyclophosphamide. Cyclophosphamide does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous.133 193 1321 1339 460 261 1053 1420 1444 402 879 160 882 1358 1399 213 1235 897 1260 786 1003 827 1381 746 680 363 710 1138 755 836 9 1270 1004 1450 217 599 552 299 1386 1023 192 486